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Next Generation Sequencing Quality Assurance

DName-iT is a MedTech Company that is applying its valuable patented DNA barcoding method to develop a revolutionary platform for labelling patients’ specimens that are analysed with Next Generation Sequencing (NGS). 

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What We Do

Genetic tests are complex and consist of many steps from patient sampling to result, all of which are prone to errors. DName-iT has developed a powerful proprietary technology that provides quality assurance throughout the entire genetic testing process. The technology is based on unique DNA barcodes or DNames™.  
 
A mismatch between the known identity of a DNA barcode and its identity as read by NGS, flags an error in the genetic testing procedure, for instance due to sample switching or tube mislabeling. DName-iT's unique quality assurance system will boost the reliability of genetic tests while maintaining patient confidentiality. DName-iT's technology also identifies sample cross contamination and allows automatic reporting.

Next to a watertight quality assurance system, DName-iT is also developing methods that remove current bottlenecks in genetic testing.

The DName-iT technologies will help to unleash the unprecedented informative power of NGS by improving accuracy, fidelity and automation of genetic tests at a reduced cost. This makes genetics analyses more affordable and accessible for more patients.
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End-to-End Quality Assurance for Genetic Testing

Genetic testing workflows are complex — from blood collection to sequencing and reporting. At every step, errors such as sample switching, tube mislabeling, or cross-contamination can occur.DName-it addresses this gap by introducing a molecular-level identity marker (“DNames™”) that persists beyond the tube and across downstream workflows, independent of handling steps.A molecular identity layer spanning pre-analytical and laboratory processing phases of NGS-based workflows.If the barcode identity does not match during NGS analysis, the system instantly flags the error.
  • No manual reconciliation.
  • No silent sample swaps.
  • No compromised results.
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How It Works

  1. Unique DNA Barcode Embedded
    Each sample is tagged with a proprietary molecular DName™.
  2. Integrated into NGS Workflow

    The barcode travels with the sample through extraction, library prep, sequencing and analysis.
  3. Automated Identity Verification
    NGS reads both the patient DNA and the DName™.
Any mismatch immediately triggers an alert.
  4. Built-in Contamination Detection & Reporting

    Cross-sample contamination is identified automatically.
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Learn more on our Products page
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